After studying graphic and industrial design at the Academy of Arts in Ghent she started her own studio in 1986, working as a freelance textile designer for Paul Smith, Calvin Klein and Esprit, among others. From 1990 her scope extended to include interior design, and she collaborated with Maarten Van Severen with whom she exhibited at the Triennial in Milan. From 1995 until the present her work has been exhibited in various leading design museums throughout the world, and in 1996 Mees received the international design award "Design for Europe", presented by Rolf Fehlbaum and Antonio Citterio at the Interieur Biennial in Kortrijk, Belgium. In 2000 Mees launched a signature collection of bed linen and plaids named "SimplePlus by Marie Mees". Currently the designer is working on various collections with companies like Arte (wallpaper), When Objects Work (John Pawson), and Casalis (carpet), as well as her own range of home textiles.